K-Laser official publications on the relevant effect of Photbiomodulation (PBM): an emerging and effective strategy for the management of multiple inflammatory condition and a supportive treatment of Immunity Activation.

Collectively the results set PBM as a safety and non-invasive procedure in oncological patients and in Chronic Inflammatory Diseases, improving patient outcome and life quality.

RELEVANT PUBBLICATIONS:

  • K-LASER CUBE

Laser Therapy Inhibits Tumor Growth in Mice by promoting Immune Surveillance and vessel Normalization. Giulia Ottaviani, Valentina Martinelli, Katia Rupel, Nicoletta Caronni, Asma Naseem, Lorenzo Zandonà, Giuseppe Perinettti, Margherita Gobbo, Roberto Di Lenarda, Rossana Bussani, Federica Benvenuti, Mauro Giacca, Matteo Biasotto, Serena Zacchigna. EBioMedicine 2016. Doi.org/10.1016/j.ebiom.2016.07.028.

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo. Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, and Serena Zacchigna. Hindawi Oxidative Medicine and Cellular Longevity Volume 2018; DOI. org/10.1155/2018/6510159

Photobiomodulation as potential novel third line tool for non-invasive treatment o

f Hidradenitis Suppurativa. Tricarico PM, Zupin L, Ottaviani G, Rupel K, Celsi F, Genovese G, Boniotto M, Crovella S, Marzano AV. G. Ital Dermatol and Venereol. 2019 Apr 23. DOI. 10.23736/S0392-0488.19.06247-3

Photobiomodulation therapy is able to decrease IL-1B gene expression in an in vitro cellular model of hidradenitis suppurativa. Ferri G, Vincelli I, Gratton R, Ottaviani G, Biasotto M, ZupinL, and Crovella S. Lasers Med Sci. 2019, Aug 23. DOI. 10.1007/s10103-019-02868-4.

Can laser therapy be the answer for radiodermatitis in anal cancer patients? Two case reports. Margherita Gobbo, Giulia Ottaviani, Katia Rupel, Matteo Biasotto and Alessandra Guglielmi. Photon Lasers Med. 2016; 5(3): 225–230. DOI. 10.1515/plm-2016-0009.

Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Margherita Gobbo, Fraia Melchionda, Rosamaria Mura, Maria Livia Mariuzzi, Nunzia Decembrino, Patrizia Defabianis, Federico Verzegnassi, Luca Ronfani, Davide Zanon, Simone Bagattoni, Alessandra Majorana, Elena Bardellini, Alessandra Piras, Maria Grazia Petris, Angelica Barone, Elisabetta Merigo, Marina Consuelo Vitale, Massimo Berger, Matteo Biasotto, Giulia Ottaviani, Giulio Andrea Zanazzo. 2017. Pediatric Blood and Cancer. 2018. DOI. 10.1002/pbc.27098.

Preliminary study in a new protocol for the treatment of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and chemotherapy (CT). Marina Consuelo Vitale, Carola Modaffari, Nunzia Decembrino, Feng Xiao Zhou, Marco Zecca, Patrizia Defabianis. Lasers Med Sci. 2017 DOI. 10.1007/s10103-017-2266-y.

Same strategy for pitfalls of radiotherapy in different anatomical districts. Margherita Gobbo, Giulia Ottaviani, Katia Rupel, Francesca Ciriello, Aulo Beorchia, Roberto Di Lenarda, Serena Zacchigna and Matteo Biasotto. Lasers Med Sci. 2016. DOI. 10.1007/s10103-015-1857-8.

Evaluation of nutritional status in head and neck radio-treated patients affected by oral mucositis: efficacy of Class IV laser therapy. M. Gobbo, G. Ottaviani, G. Perinetti, F. Ciriello, A. Beorchia, M. Giacca, R. Di Lenarda, K. Rupel, G. Tirelli, S. Zacchigna and M. Biasotto. Support Care Cancer. 2014. DOI. 10.1007/s00520-014-2155-x.

Class IV laser therapy as treatment for chemotherapy-induced oral mucositis in onco-haematological paediatric patients: a prospective study. Maddalena Chermetz, Margherita Gobbo, Luca Ronfani, Giulia Ottaviani, Giulio A. Zanazzo, Federico Verzegnassi, Nathaniel S. Treister, Roberto Di Lenarda, Matteo Biasotto and Serena Zacchigna. International Journal of Pediatric Dentistry. 2013. DOI. 10.1111/ipd.12090.

Laser surgical treatment of chronic graft-versus-host disease (cGvHD)-induced buccal mucosal sclerosis. Katia Rupel, Margherita Gobbo, Giulia Ottaviani and Matteo Biasotto. Photon Lasers Med. 2015; 4(3): 253–257.

  • K-LASER  BLUE DERMA

Blue laser light inhibits biofilm formation in vitro and in vivo by inducing oxidative stress. Katia Rupel, Luisa Zupin, Giuia Ottaviani, Iris Bertani, Valentina Martinelli, Davide Porrelli, Simone Vordet, Roman Vuerich, Daniel Passos da Silva, Rossana Bussani, Sergio Crovella, Mattew Parsek, Vittorio Venturi, Roberto Di Lenarda, Matteo Biasiotto and Serena Zacchigna. Npj Biofilms and Microbiomes (2019) 5:29 Nature partners journals. http://doi.org/10.1038/s41522-019-0102-9.

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